MOG 35-55 Peptide GMP Supplier in China|High-Purity Myelin Oligodendrocyte Glycoprotein 35-55 API for EAE Model Research & Bulk Wholesale Supply
- High-purity MOG 35–55 peptide
What Is MOG 35-55 Peptide (Myelin Oligodendrocyte Glycoprotein 35-55) and What Is It Used For in Neuroimmunology Research?
MOG 35-55 peptide (Myelin Oligodendrocyte Glycoprotein 3555) is a 21-amino-acid synthetic linear peptide derived from the immunodominant extracellular region of mouse myelin oligodendrocyte glycoprotein (MOG).
It is widely used as a standard antigen for inducing experimental autoimmune encephalomyelitis (EAE), the most widely accepted animal model of multiple sclerosis.
This product is supplied as a white to off-white powder manufactured under GMP-compliant Fmoc solid-phase peptide synthesis (SPPS), followed by multi-step preparative HPLC purification and desalting.
Mass spectrometry confirms accurate molecular weight and high sequence fidelity, with no detectable foreign protein or pyrogen contamination.
What Does the COA Include for MOG 35-55 peptide?
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>=99% |
99.42% |
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What Are the Advantages of MOG 35-55 Peptide Quality Control?
- Low endotoxin minimizes non-specific inflammatory interference
- Strong antigen specificity for precise MOG-targeted immune response
What Are the Pharmacological Research Functions of MOG 35-55?
- Activation of MOG-specific CD4+ T-cell immune responses
- Promotion of inflammatory cytokines such as IL-17 and IFN-
- Generation of anti-MOG antibody response in vivo
What Are the Applications of MOG 35-55 Peptide?
- Immune-modulating drug screening and evaluation
- Anti-MOG antibody development (monoclonal and polyclonal)
- Diagnostic assay development for MOG-related biomarkers
What Are the Core Manufacturing Advantages of This MOG 35-55 peptide?
- GMP-controlled Fmoc solid-phase peptide synthesis ensures sequence accuracy
- Multi-step HPLC purification removes truncated and deletion impurities
What Is the Mechanism of Action of MOG 35-55 in Immune Activation?
- In vivo, MOG 35-55 is processed by antigen-presenting cells and presented via MHC-II molecules, leading to activation of MOG-specific CD4+ T cells. Activated T cells migrate to the central nervous system, triggering inflammatory infiltration and demyelination, thereby mimicking multiple sclerosis pathology.
- In vitro, the peptide stimulates lymphocyte proliferation and cytokine release, enabling immune profiling and pharmacological inhibition studies.
How Is Quality Assurance Ensured in GMP Manufacturing of MOG 35-55?
- GMP-compliant cleanroom production system with contamination control
- Multi-layer QC testing: HPLC, MS, sequence validation, endotoxin testing
- Long-term stability studies at -20℃ storage conditions
- Optional third-party verification for regulatory research use
Q1: What is MOG 35-55 peptide used for?
A: MOG 35-55 peptide induces EAE mouse model to study multiple sclerosis and neuroautoimmunity research.
Q2: What's the sequence of mouse MOG 35-55 peptide?
A: MEVGWYRSPFSRVVHLYRNGK, 21 amino acid immunodominant epitope.
Q3: Can MOG 35-55 be used for human clinical injection?
A: No, only for laboratory preclinical animal research.
Where to Buy GMP MOG 35-55 Peptide?
We supply high-purity MOG 35-55 peptide (Myelin Oligodendrocyte Glycoprotein 3555) manufactured under strict GMP conditions, supporting global neuroimmunology and autoimmune disease research.
WhatsApp: +8619991242181
sales@hdmbio.com
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